Bringing structure visualization capabilities to the MINERVA platform. Right click on any node representing a protein, to bring up the context menu via which you can access MolArt.
An online resource developed at the Stanley Center in the Broad Institute of MIT and Harvard. The goal of MISCAST is to interpret single amino-acid-altering missense variants on protein 3-dimensional structure and to thereby forcast their biological impact. MolArt facilitates visualization of pathogenic and population variants and contrast them with a plethora of structure-derived features.
The Nullomers Database is a web-based resource which aims to facilitate exploration of biological nullomers (a.k.a. minimal absent words). Its purpose is to catalogue and share statistically significant non-occurring sequences which are unexpectedly absent in several genomes and proteomes.
A single-page example showcasing the plugin on the example of Alpha-synuclein, a protein which accumulates in the brain cells of patients with Parkinson's disease. The mapped structure with PDB ID 2N0A nicely shows the fibrils. Similar structure can be also seen in tau protein in Alzheimer's disease.